Principal Investigators

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Dr. Vincent Prevot Ph.D

Lab Director

Lead researcher and head of the laboratory. Click here to find out more about Vincent’s work

 

 

 

 

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Dr. Sebastien Bouret Ph.D

Principal Researcher & Group Leader

Jointly based between the University of Southern California (USC) and our Laboratory, Sebastien’s work is focused on changes to hypothalamic rewiring that impacts the control of metabolic feedback loops and targeting methods to treat obesity disorders. Click here to find out more about Sebastien’s work.

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Dr. Benedicte Dehouck Ph.D

Principal Researcher & Lecturer (University of Artois)

Study of blood-brain interfaces in contributing to the delivery of blood-borne molecules to their neuronal targets.Click here to find out more about Benedicte’s work

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Dr. Paolo Giacobini Ph.D

Principal Investigator & Group Leader

Expert on developmental neuroscience and neuronal migration.Click here to find out more about Paolo’s Research

 

 

 

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Dr. Ariane Sharif Ph.D

Principal Researcher & Lecturer (University of Lille 2)

Ariane’s Research focuses on the importance of glial cells in regulating neuroendocrine processes and targeting therapeutic interventions for glioblastomas

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Dr. Marc Baroncini M.D, Ph.D

Principal Researcher & Neurosurgeon (CHRU)

Marc is a renowned neurosurgeon at Lille’s Regional Hospital Centre (CHRU) and his research focuses on hypothalamic control of metabolism with regards to eating disorders 

 

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Clinical Partners

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Professor Didier Dewailly M.D

Head of Gynaecology, Endocrine and Reproductive Medicine, Professor & Practitioner, Jeanne de Flandre Hospital

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure

Curriculum Vitae

 

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Professor Claude-Alain Maurage M.D

Anatomopathologist, Pathology Dept

 

 

Clinical Partners

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Dr. Sophie Catteau-Jonard M.D Ph.D

Assistant Professor & Practitioner, Jeanne de Flandre Hospital 

 

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure 

 

 

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Technicians

Daniele Mazur

ResponsibilitiesMaintenance and utilization of the cryostats, microtomes etc.Perfusion RoomKey TechniquesImmunohistochemistry, ImmunofluorescencePublicationsParkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P.Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014 

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Anne Loyens

Assistant Engineer

ResponsibilitiesElectron MicroscopeCell Culture RoomKey TechniquesImmunohistochemistry, Immunofluorescence, Cell Culture, Electron Microscopy, ISHPublicationsParkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P.Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V. Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence. Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870. 

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Dr. Cecile Allet Ph.D

Ingénieur de recherche

Education

Thèse de doctorat de l’Université de Lille 2 “Gliogenèse dans l’hypothalamus au cours du développement postnatal: implication dans le contrôle de la maturation sexuelle femelle”

ResponsibilitiesResponsable du plateau de microscopie photonique du Centre JPArcResponsable du parc de balances du Centre JPArcAdditional TrainingMicroscopie photonique, Microscopie électronique, Microscopie à feuille de lumière, Immunohistochimie, hybridation in situ, histologie du cerveau rongeur et humainExpérimentation animalePublications

Casoni et al, Development. 2016; 143(21):3969-3981

Delavalle et al, Exp Cell Res. 2011; 317(18):2683-94

Lee-Chang et al, Immunol lett. 2011; 135(1-2):108-17

Prevot et al, Front Neuroendocrinol. 2010; 31(3):241-58

Venna et al, Psychoneuroendocrinology. 2009; 34(2):199-211

Sharif et al, Glia. 2009; 57(4):362-79

Baroncini et al, J Neuroendocrinol. 2007; 19(9):691-702

Sharif et al, Oncogene. 2007; 26(19):2695-706

Sharif et al, Oncogene. 2006: 25(29):4076-85

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Engineers

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Dr. Emilie Caron Ph.D

 Research Engineer

Head of the core for murine metabolic phenotyping

EducationPh.D University of Lille 2 “Leptin & hypothalamic regulation of reproductive function in mice” 2006M.Sc. Neuroscience, University of Lille 2, France, 2003.ResponsibilitiesMaintenance and Use of Metabolic CagesPublicationsNeonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG. Mol Metab. 2015, 4(1):15-24.Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175)Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction? Méquinion M, Caron E, Zgheib S, Stievenard A, Zizzari P, Tolle V, Cortet B, Lucas SPrévot V, Chauveau C, Viltart O. Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E241-55

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Sarah Gallet

Study Engineer

Curriculum Vitae

Supervisor: Dr. Vincent Prevot

Impact of melatonin hormone on the blood-brain-barrier at the level of the median eminence

EducationM.Sc. Biology Biotechnology, University of Lille, 2011ResponsibilitiesResponsible for L2 Cell CultureRegistrar of GMO databaseAdditional TrainingAnimal Experimentation Level I (IV, IP, intracardiac perfusion)PublicationsParkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P.Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014

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Post Docs

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Dr. Maria Manfredi Lozano Ph.D

Supervisor: Dr. Vincent Prevot

 

 

 

Supported by the Marie Skłodowska-Curie action – Research Fellowship Programme

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Dr. Monica Imbernon Ph.D

Curriculum Vitae 

Supervisor: Dr. Vincent Prevot

 

 

 

Supported by the Marie Skłodowska-Curie action – Research Fellowship Programme

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Dr. Daniela Fernandois Ph.D

Supervisor: Dr. Vincent Prevot

 

 

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Dr. Konstantina Chachlaki Ph.D

Curriculum Vitae

Supervisors: Dr. Vincent Prevot, Pr. John Garthwaite (UCL)

EducationPh.D in Neuroscience: University of Lille 2. 2016M.Sc. Brain and Mind Sciences: University College London (UCL), University Pierre and Marie Curie (UPMC), École Normale Supérieure (ENS) 2010-2012Molecular Biology Diploma: University of Crete, 2010-2006PublicationsChachlaki et al., Nat Rev Endocrin,10.1038/nrendo.2017.69. 2017Chachlaki et al., J Comp Neurol, 10.1002/cne.24257. 2017Chachlaki & Prevot, PNAS1600717113, 2016.Messina A et al., Nature Neuroscience 19, 835–844 (2016)Alterio J et al., Traffic 16(9) 2015Bellefontaine N et al., J Clin Invest 124:2550-2559, 2014.Bhargava Y et al., Front Mol Neurosci.6:26, 2013

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Dr. Samuel Malone Ph.D

  Curriculum Vitae

Supervisor: Dr. Paolo Giacobini

Anti-Müllerian hormone and the development of the gonadotropin-releasing hormone (GnRH) neuronal system

EducationM.Sc. Neuroscience, University of Lille 2, France, 2014.B.Sc. Hons. Anatomical Science, University of Bristol, United Kingdom, 2012 Publications

Chachlaki et al., J Comp Neurol, 10.1002/cne.24257. 2017

Belle et al., Cell. 2017, (3)008

Casoni & Malone et al., Development. 2016, 1;143(21):3969-3981

Parkash et al., Nat Commun. 2015, 6:6385 

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Dr. Giuliana Pellegrino Ph.D

Curriculum Vitae

Supervisor: Dr. Ariane Sharif

Cell neogenesis in the hypothalamus: a new mechanism of control of reproductive function

EducationM.Sc. Cellular and Molecular Biology, University of Turin, Italy 2012-14B.Sc. Biological Science, University of Catania, Italy, 2008-11Publications

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Dr. Sara Trova Ph.D

Supervisor: Dr. Paolo Giacobini

EducationPh.D. Neuroscience, University of Turin, Italy 2014-18M.Sc. Cellular and Molecular Biology, University of Turin, Italy 2012-14

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Dr. Mauro Silva Ph.D

Supervisor: Dr. Paolo Giacobini

EducationPh.D. Neuroscience, University of Otago, New Zealand 2014-18

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Doctoral Students

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Manon Duquenne

 

Supervisor: Dr. Vincent Prevot

The importance of calcium dependent exocytosis in the tanycyte mediated transport of leptin

EducationMaster 1 Research Physiology et Physiopathology of human diseases, Lille 1 and Lille 2 University, France

Dr Vincent Florent MD

 

Supervisor: Dr. Marc Baroncini

Hypothalamic communication with the periphery research in humans: impact on the cerebral metabolic activity and the control of energy homeostasis

EducationM.Sc Paris VII Diderot: Nutrition, metabolism, signaling. FranceMedic`l doctor and hospital practitioner, Arras General HospitalGraduate of complementary specialized studies in nutritionUniversity degree: Human nutrition & public healthUniversity degree: Clinical research

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Valerie Leysen

 

Supervisor: Dr. Vincent Prevot

EducationBiomedical sciences, University of Antwerp, Belgium, 2014. M.Sc. Neuroscience, University of Antwerp, Belgium, 2016.

Nour El Houda Mimouni

Supervisor: Dr. Paolo Giacobini

EducationMaster Reproduction and development, University of Paris VII

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Dr. Anne-Laure Barbotin MD

 

Supervisor: Pr. Sophie Catteau-Jonard & Dr. Valerie Mitchell

Neurostructural hypothalamic plasticity in polycystic ovary syndrome

EducationMaster 2, Paris V University, France

Dr. Maëliss Peigné MD

 

Supervisor: Pr. Sophie Catteau-Jonard 

Mégane Pièt

 

Supervisor: Dr. Benedicte Dehouck 

Implication of the plasticity of the blood brain barrier in the establishment of obesity: cellular and molecular mechanisms regulating the access of peripheral signals to the arcuate nucleus

EducationMaster 2, University of Rouen, France

Marion Martin

 

Supervisor: Dr. Ariane Sharif

EducationMaster 2,  France

 

Romain Ouin

 

Supervisor: Dr. Ariane Sharif

Involvement of the Hippo pathway in hypothalamic cells

EducationMaster 1 Research Physiology et Physiopathology of human diseases, Lille 1 and Lille 2 University, France

Tori Lhomme

 

Supervisor: Dr. Vincent Prevot

The tanycyte-neuron lactate shuttle: a new control mechanism of the neuronal circuits regulating appetite

EducationMaster 1 Research Physiology et Physiopathology of human diseases, Lille 1 and Lille 2 University, France