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Vincent Prevot’s research focuses on Systems Neuroscience and Neuroendocrinology, in particular the brain circuits that control reproduction and metabolism and the neural pathways through which they respond to peripheral information.
Expert on developmental neuroscience and neuronal migration.
Paolo Giacobini’s research focuses on understanding the neuronal control of reproduction and the molecular mechanisms underlying fertility disorders.
Expert in the neuroendocrinology of obesity. Sebastien’s general research interest is to study the role of the perinatal environment and neurodevelopmental mechanisms in lifelong obesity and metabolism.Find out more about Sebastien’s work.
Expertise in : Vascular biology (angiogenesis, endothelial activation, endothelial cell functions and properties) and vascular extracellular matrix. Ongoing projects: Tissue biophysical properties in the communication between the periphery and the brain: specific roles of blood vessels and extracellular matrix.
With a strong background in vascular biology, my research focuses on the study of the interactions between endothelial cells and tanycytes in the median eminence of the hypothalamus, and on the communication between tanycytic populations.
Study of blood-brain interfaces in contributing to the delivery of blood-borne molecules to their neuronal targets.
Marc is a neurosurgeon, hospital practitioner at the University Hospital of Lille. He is interested in the anatomy of the hypothalamus, hypothalamic control of metabolism and deregulation in eating disorders. He is also involved in the surgical pathology of cerebrospinal fluid.
Neuropathology of dementing disorders affecting the hypothalamus and development of DNA-methylation profile assays for non-tumoral hypothalamic pathologies.
Studies : Doctoral thesis of the University of Lille “Gliogenesis in the hypothalamus during postnatal development: implication in the control of female sexual maturation”.
Responsibilities: Responsible for the light microscopy platform of the Center. Responsible for the Center balance park.
Additional training: Sound microscopy, Electron microscopy, Light sheet microscopy, Immunohistochemistry, in situ hybridization, rodent and human brain histology, Animal experimentation.
Casoni et al, Development. 2016; 143(21):3969-3981 Delavalle et al, Exp Cell Res. 2011; 317(18):2683-94 Lee-Chang et al, Immunol lett. 2011; 135(1-2):108-17
Prevot et al, Front Neuroendocrinol. 2010; 31(3):241-58 Venna et al, Psychoneuroendocrinology. 2009; 34(2):199-211
Sharif et al, Glia. 2009; 57(4):362-79
Baroncini et al, J Neuroendocrinol. 2007; 19(9):691-702 Sharif et al, Oncogene. 2007; 26(19):2695-706
Sharif et al, Oncogene. 2006: 25(29):4076-85.
Studies: Doctoral thesis from the University of Lille 2 “Leptin and hypothalamic regulation of reproductive function in mice” 2006. Research master’s degree in Neuroscience, University of Lille 2, 2003.
Responsibilities: Maintenance and use of metabolic cages.
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG. Mol Metab. 2015, 4(1):15-24.
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175).
Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction? Méquinion M, Caron E, Zgheib S, Stievenard A, Zizzari P, Tolle V, Cortet B, Lucas S, Prévot V, Chauveau C, Viltart O. Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E241-55.
Studies : M.Sc. Biology Biotechnology, University of Lille, 2011.
Responsibilities: Responsible for L2 Cell Culture. Registrar of GMO database.
Additional Training: Animal Experimentation Level I (IV, IP, intracardiac perfusion).
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control
Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.
Responsibilities: Maintenance and utilization of the cryostats, microtomes etc. Perfusion Room.
Key techniques: Immunohistochemistry, immunofluorescence, electron microscopy.
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK,
Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.
