Principal Investigators

Dr. Vincent Prévot, Ph.D

Lab Director
Lead researcher and head of the laboratory

Vincent Prevot’s research focuses on Systems Neuroscience and Neuroendocrinology, in particular the brain circuits that control reproduction and metabolism and the neural pathways through which they respond to peripheral information.

Group Leader
Principal Investigator

Expert on developmental neuroscience and neuronal migration.
Paolo Giacobini’s research focuses on understanding the neuronal control of reproduction and the molecular mechanisms underlying fertility disorders.

Group Leader
Principal Investigator

Expert in the neuroendocrinology of obesity. Sebastien’s general research interest is to study the role of the perinatal environment and neurodevelopmental mechanisms in lifelong obesity and metabolism.Find out more about Sebastien’s work.

Dr Virginie Mattot, Ph.D.

Principal Investigator &
Group Leader

Expertise in : Vascular biology (angiogenesis, endothelial activation, endothelial cell functions and properties) and vascular extracellular matrix. Ongoing projects: Tissue biophysical properties in the communication between the periphery and the brain: specific roles of blood vessels and extracellular matrix.

Dr. Ines Martinez Corral

Principal Investigator &
Group Leader

With a strong background in vascular biology, my research focuses on the study of the interactions between endothelial cells and tanycytes in the median eminence of the hypothalamus, and on the communication between tanycytic populations.

Dr. Ariane Sharif, Ph.D.

Principal Researcher & Lecturer.

Ariane’s Research focuses on the importance of glial cells in regulating neuroendocrine processes and targeting therapeutic interventions for glioblastomas.

Dr. Bénédicte Dehouck, Ph.D.

Principal Researcher & Lecturer.

Study of blood-brain interfaces in contributing to the delivery of blood-borne molecules to their neuronal targets.

Dr. Marc Baroncini, M.D, Ph.D.

Principal Researcher & Neurosurgeon (CHRU)

Marc is a neurosurgeon, hospital practitioner at the University Hospital of Lille. He is interested in the anatomy of the hypothalamus, hypothalamic control of metabolism and deregulation in eating disorders. He is also involved in the surgical pathology of cerebrospinal fluid.

Dr. Vincent Florent, M.D, Ph.D.

PH in nutrition (CH Arras)

Vincent is a hospital physician specializing in clinical nutrition, metabolism and eating disorders. He is conducting several translational studies including the study of the communication of the hypothalamus with the periphery in humans. He has designed an innovative virtual reality therapeutic game program called VERTEXA, aimed at treating eating disorders.

Scientific Coordinators of European Projects

Dr. Sowmyalakshmi Rasika, Ph.D.

Contract Researcher; WATCH project

Dr. Konstantina Chachlaki, Ph.D.

Contract Researcher; miniNO project

Clinical Partners

Pr. Didier Dewailly, PU-PH, M.D, Ph.D.

Head of Gynaecology, Endocrine and Reproductive Medicine, Professor & Practitioner. Professeur Emeritus.

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure. Curriculum Vitæ

Dr. Sophie Catteau-Jonard, PU-PH, M.D, Ph.D.

PU-PH in Reproductive Biology
Head of Gynecology-Infertility-Medical Assistant for Procreation and Fertility Preservation
Hôpital Jeanne de Flandre, (CHU Lille

Principal Research Areas: Ovulation disorders including polycystic ovary syndrome, hypothalamic amenorrhea, hypogonadic hypogonadism and premature ovarian failure.

Pr. Claude-Alain Maurage, M.D., Ph.D.

Anatomopathologist, Pathology Dept.

Head of the Institute of Pathology Center of Biology Pathology Genetics,(CHU Lille).

Neuropathology of dementing disorders affecting the hypothalamus and development of DNA-methylation profile assays for non-tumoral hypothalamic pathologies.

Dr. Anne-Laure Barbotin, M.D, Ph.D.

MCU-PH in Reproductive Biology, (CHU Lille)

Neurostructural hypothalamic plasticity in polycystic ovary syndrome. Formation : Master 2, Paris V University, France.

Post Docs

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Vincent Prévot.
Supported by the Marie Sktodowska-Curie
action – Research Fellowship Programme Hôpital Jeanne de Flandre, (CHU Lille

Supervisor : Dr. Vincent Prévot.

Supervisor : Dr. Vincent Prévot

Supervisor: Dr. Paolo Giacobini

Supervisor: Dr. Paolo Giacobini

Supervisor: Dr. Paolo Giacobini

Doctoral Students

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Ariane Sharif
Formation : Master 2, France

Supervisor : Pr. Sophie Catteau-Jonard

Supervisor : Dr. Vincent Prévot

Supervisor: Dr. Paolo Giacobini

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Virginie Mattot

Supervisor : Dr. Ariane Sharif

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Vincent Prévot

Supervisor : Dr. Sébastien Bouret

Supervisor : Dr. Bénédicte Dehouck

Supervisor : Dr. Paolo Giacobini

Engineers

Dr. Cécile Allet, Ph.D.

Research Engineer
Supervisor: Dr. Paolo Giacobini

Studies : Doctoral thesis of the University of Lille “Gliogenesis in the hypothalamus during postnatal development: implication in the control of female sexual maturation”.

Responsibilities: Responsible for the light microscopy platform of the Center. Responsible for the Center balance park.

Additional training: Sound microscopy, Electron microscopy, Light sheet microscopy, Immunohistochemistry, in situ hybridization, rodent and human brain histology, Animal experimentation.

Casoni et al, Development. 2016; 143(21):3969-3981 Delavalle et al, Exp Cell Res. 2011; 317(18):2683-94 Lee-Chang et al, Immunol lett. 2011; 135(1-2):108-17

Prevot et al, Front Neuroendocrinol. 2010; 31(3):241-58 Venna et al, Psychoneuroendocrinology. 2009; 34(2):199-211

Sharif et al, Glia. 2009; 57(4):362-79

Baroncini et al, J Neuroendocrinol. 2007; 19(9):691-702 Sharif et al, Oncogene. 2007; 26(19):2695-706

Sharif et al, Oncogene. 2006: 25(29):4076-85.

Dr. Émilie Caron, Ph.D.

Research Engineer
Responsible for the murine metabolic phenotyping platform.

Studies: Doctoral thesis from the University of Lille 2 “Leptin and hypothalamic regulation of reproductive function in mice” 2006. Research master’s degree in Neuroscience, University of Lille 2, 2003.

Responsibilities: Maintenance and use of metabolic cages.

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG. Mol Metab. 2015, 4(1):15-24.

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175).

Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction? Méquinion M, Caron E, Zgheib S, Stievenard A, Zizzari P, Tolle V, Cortet B, Lucas S, Prévot V, Chauveau C, Viltart O. Am J Physiol Endocrinol Metab. 2015 Feb 1;308(3):E241-55.

Sarah Gallet

Study Engineer
Scientific Supervisor : Dr. Vincent Prévot
Impact of melatonin hormone on the
blood-brain-barrier at the level of the
median eminence

Curriculum Vitæ

Studies : M.Sc. Biology Biotechnology, University of Lille, 2011.

Responsibilities: Responsible for L2 Cell Culture. Registrar of GMO database.

Additional Training: Animal Experimentation Level I (IV, IP, intracardiac perfusion).

Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.

Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control

Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.

Assistants Engineers

Danielle Mazur

Assistant Engineer

Responsibilities: Maintenance and utilization of the cryostats, microtomes etc. Perfusion Room.

Key techniques: Immunohistochemistry, immunofluorescence, electron microscopy.

Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP,Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P. Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence. Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.

Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK,

Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V. Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A. PLoS Biology 12(3):e1001808, 2014.

Amandine Legrand

Engineers Assistant

Gaspard Delpouve

Temporary Engineers Assistant

Alumni

Post Doctoral Research Fellow,
University of Michigan.
Moenter Lab, Molecular & Integrative
Physiology Department.

Post Doctoral Research Fellow,
University of Cambridge.
Yeo Lab, Metabolic Research.

Post Doctoral Fellow,
University of Monash, Zane Lab, Australia.

Post Doctoral Research Fellow, German Research Centre for Environmental Health (GmbH). Institute for Diabetes and Obesity. Tschöp Lab.

Assistant Professor
Central University of Punjab, Bhatinda, India.

Research Manager
University Hospital of Lausanne,
Switzerland, Pitteloud Lab

Assistant Professor
Universita Vita-Salute Sane Raffaele Milan

Ph.D Student

Group Leader at the UNIL,
Lausanne, Switzerland.

Group Leader at the Monash University, Australia.

Post Doc, Fred Hutchinson Cancer Research Centre, Seattle

Group Leader at the Max Planck Institute for Metabolism Research, Köln, Germany.

Miguel Servet Investigator
Instituto de Biomedicina de Sevilla, Seville

Postdoctoral fellow at the Meiji University, Tokyo, Japan

Scientific and technical Manager at Bordeaux School of Neuroscience, France

Postdoctoral Research Scientist
Department of Physiology,
Anatomy and Genetics, Domingos’ Lab,
University of Oxford

Upstream Data Coordinator,
UCB Pharma, Belgium

Postdoctoral Fellow
Instituto de Biomedicina de Sevilla,
D’anglemont de Tassigny’s Lab, Spain.

Senior Scientist Epilepsy
Team Leader at UCB BioPharma, Belgium