Original Research Articles
2019
Hypothalamic structural and functional imbalances in anorexia nervosa.
Florent V, Baroncini M, Jissendi-Tchofo P, Lopes R, Vanhoutte M, Rasika S, Pruvo JP, Vigneau J, Verdun S, Johansen J, Pigeyre M, Bouret S, Nilsson I, Prevot V
Neuroendocrinology. 2019. doi:10.1159/000503147
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism.
Malone SA, Papadakis GE, Messina A, Mimouni NEH, Trova S, Imbernon M, Allet C, Cimino I, Acierno J, Cassatella D, Xu C, Quinton R, Szinnai G, Pigny P, Alonso-Cotchico L, Masgrau L, Maréchal JD, Prevot V, Pitteloud N, Giacobini P.
Elife. 2019. doi: 10.7554/eLife.47198
Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS.
Cell. 2019. doi: 10.1016/j.cell.2018.12.009
2018
Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood
Tata BK, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Classadonte J, Giacobini P
Nature Medicine. 2018. doi:10.1038/s41591-018-0035-5
A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (Microcebus murinus)
Pellegrino G, Trubert C, Terrien J, Pifferi F, Leroy D, Loyens A, Migaud M, Baronicini M, Maurage CA, Fontaine C, Prevot V, Sharif A
J Comp Neurol. 2018. doi: 10.1002/cne.24376
Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis.
Croizier S, Park S, Maillard J, Bouret SG.
Elife. 2018. doi: 10.7554/eLife.40429.
2017
Phenotyping of nNOS Neurons in the Postnatal and Adult Female Mouse Hypothalamus
Chachlaki K, Malone SA, Qualls-Creekmore, Hrabovszky E, Munzberg H, Giacobini P, Ango F, Prevot V
J Comp Neurol. 2017. 10.1002/cne.24257
Tridimensional Visualization and Analysis of Early Human Development
Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chedotal A
Cell. 2017 DOI: http://dx.doi.org/10.1016/j.cell.2017.03.008
2016
Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
Casoni F, Malone SA, Belle M, Luzzati F, Collier F, Allet C, Hrabovszky E, Rasika S, Prevot V, Chédotal V, Giacobini P
Development. 2016 143: 3969-3981; doi: 10.1242/dev.139444
Leptin controls parasympathetic wiring of the pancreas during embryonic life
Croizier S, Prevot V, Bouret SG
Cell Reports. 2016 15, 36-44,
Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits
Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, and Bouret
Hum Mol Genet. 25:3208-3215, 2016
A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V
Nat Neurosci. 2016 19, 835-844 doi:10.1038/nn.4298
Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion
Cimino I, Casoni F, Liu X, Messina A, Parkash J, Soazik P, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison A, Prevot V, Giacobini P
Nat Commun. 2016, 7:10055
2015
Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP, Cagnoni, Schellino R, De Marchis, Mazzone M, Pasterkamp JR, Tamagnone L, Prevot V, Giacobini P
Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.
Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin
Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG.
Mol Metab. 2015, 4(1):15-24.
Neonatal ghrelin programs development of hypothalamic feeding circuits
Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, and Bouret SG.
J Clin Invest. 2015, 125(2):846-58.
2014
Leptin dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction
Bellefontaine N, Chachlaki K, Parkash J, Vanaker C, Colledge W, d’Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V.
J Clin Invest 124:2550-2559, 2014.
Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A
Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V.
PLoS Biology 12(3):e1001808, 2014.
Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain
Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.
Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175)
2013
Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain
Langlet F, Muller A, Bouret SG, Prevot V, Dehouck B.
J Comp Neurol. 2013521(15):3389-405 doi: 10.1002/cne.23355
Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting
Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B .
Cell Metab. 2013 Apr 2;17(4):607-17. doi: 10.1016/j.cmet.2013.03.004..
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons
Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P.
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7. doi:10.1073/pnas.1212137110.
2012
Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations.
Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, Prevot V, Giacobini P.
J Neurosci. 2012 Nov 21;32(47):16992-7002. doi: 10.1523/JNEUROSCI.3057-12.2012.
RIPping off GABA release in hypothalamic circuits causes obesity.
Bouret SG.
Cell Metab. 2012 Nov 7;16(5):557-8. doi: 10.1016/j.cmet.2012.10.014.
SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.
Hanchate NK, Giacobini P, Lhuillier P, Parkash J, Espy C, Fouveaut C, Leroy C, Baron S, Campagne C, Vanacker C, Collier F, Cruaud C, Meyer V, García-Piñero A, Dewailly D, Cortet-Rudelli C, Gersak K, Metz C, Chabrier G, Pugeat M, Young J, Hardelin JP, Prevot V, Dodé C.
PLoS Genet. 2012 Aug;8(8):e1002896. doi: 10.1371/journal.pgen.1002896.
Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function.
Caron E, Ciofi P, Prevot V, Bouret SG.
J Neurosci. 2012 Aug 15;32(33):11486-94. doi: 10.1523/JNEUROSCI.6074-11.2012.
Embryonic birthdate of hypothalamic leptin-activated neurons in mice.
Ishii Y, Bouret SG.
Endocrinology. 2012 Aug;153(8):3657-67. doi: 10.1210/en.2012-1328.
Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation.
Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG.
Cell Metab. 2012 Feb 8;15(2):247-55. doi: 10.1016/j.cmet.2011.12.016.
Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits.
Bouret SG, Bates SH, Chen S, Myers MG Jr, Simerly RB.
J Neurosci. 2012 Jan 25;32(4):1244-52. doi: 10.1523/JNEUROSCI.2277-11.2012.
Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.
Hanchate NK, Parkash J, Bellefontaine N, Mazur D, Colledge WH, d’Anglemont de Tassigny X, Prevot V.
J Neurosci. 2012 Jan 18;32(3):932-45. doi: 10.1523/JNEUROSCI.4765-11.2012.
MRI atlas of the human hypothalamus.
Baroncini M, Jissendi P, Balland E, Besson P, Pruvo JP, Francke JP, Dewailly D, Blond S, Prevot V.
Neuroimage. 2012 Jan 2;59(1):168-80. doi: 10.1016/j.neuroimage.2011.07.013.
2011
Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility.
Messina A, Ferraris N, Wray S, Cagnoni G, Donohue DE, Casoni F, Kramer PR, Derijck AA, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P.
Hum Mol Genet. 2011 Dec 15;20(24):4759-74. doi: 10.1093/hmg/ddr403.
Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.
Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V.
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16104-9. doi: 10.1073/pnas.1107533108.
Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring.
Steculorum SM, Bouret SG.
Endocrinology. 2011 Nov;152(11):4171-9. doi: 10.1210/en.2011-1279.
2010
Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle.
Parkash J, d’Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buée-Scherrer V, Prevot V.
Endocrinology. 2010 Jun;151(6):2723-35. doi: 10.1210/en.2010-0007.
Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence.
De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V.
Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870.
Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
Mullier A, Bouret SG, Prevot V, Dehouck B.
J Comp Neurol. 2010 Apr 1;518(7):943-62. doi: 10.1002/cne.22273.
Distribution of leptin-sensitive cells in the postnatal and adult mouse brain.
Caron E, Sachot C, Prevot V, Bouret SG
J Comp Neurol. 2010 Feb 15;518(4):459-76. doi: 10.1002/cne.22219.
Sex steroid hormones-related structural plasticity in the human hypothalamus.
Baroncini M, Jissendi P, Catteau-Jonard S, Dewailly D, Pruvo JP, Francke JP, Prevot V.
Neuroimage. 2010 Apr 1;50(2):428-33. doi: 10.1016/j.neuroimage.2009.11.074.
Summary of Articles for General Audience
Review Articles
2019
Nitric oxide signalling in the brain and its control of bodily functions.
Chachlaki K, Prevot V.
Br J Pharmacol.2019. doi: 10.1111/bph.14800.
Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function.
Barbotin AL, Peigné M, Malone SA, Giacobini P
Neuroendocrinology. 2019. doi: 10.1159/000500689.
Don’t Trust Your Gut: When Gut Microbiota Disrupt Fertility.
Silva MSB, Giacobini P.
Cell Metab. 2019. doi: 10.1016/j.cmet.2019.09.005.
New Developments in Reproductive and Stress Neuroendocrinology.
Prevot V, Millar RP.
Neuroendocrinology. 2019. doi: 10.1159/000502420.
2018
The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism
Prevot V, Dehouck B, Sharif A, Ciofi P, Giacobini P, Clasadonte J
Endocrine Reviews. 2018. 1;39(3):333-368. doi: 10.1210/er.2017-00235
The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus
Clasadonte J & Prevot V
Nature Reviews Endocrinology. 2018, doi:10.1038/nrendo.2017.124
2017
The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus
Chachlaki K, Garthwaite J, Prevot V
Nature Reviews Endocrinology. 2017, doi:10.1038/nrendo.2017.69
Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility
Manfredi-Lozano M, Roa J, Tena-Sempere M
Frontiers in Neuroendocrinology. 2017, doi: 10.1016/j.yfrne.2017.07.008
When size matters: how astrocytic processes shape metabolism
Sharif A, Prevot V
Cell Metabolism. 2017, doi:10.1016/j.cmet.2017.04.016
2016
Hypothalamic microRNAs flip the switch for fertility
Messina A, Prevot V
Oncotarget. 2016, DOI: 10.18632/oncotarget.14646
Reproduction: A kiss to set the rhythm
Shruti S, Prevot V
elife. 2016, doi:e19823
Programming the Brain from the Womb: Maternal Obesity Perturbs the Hypothalamic Blood-Brain Barrier
Duquenne, M., Dehouck, B. & Prevot, V
Endocrinology, 157:2201-2203, 2016
Coexpression profiles reveal hidden gene networks
Chachlaki & Prevot
PNAS (doi: 10.1073/pnas.1600717113)
2015
European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
Boehm U., Bouloux P.M., Dattani M.T., de Roux N., Dodé C., Dunkel L., Dwyer A.A., Giacobini P., Hardelin JP., Juul A., Maghnie M., Pitteloud N., Prevot V., Raivio T., Tena-Sempere M., Quinton R. and Young J. (2015).
Nature Reviews Endocrinology (doi:10.1038/nrendo.2015.112)
Shaping the Reproductive System: Role of Semaphorins in Gonadotropin-Releasing Hormone Development and Function
Giacobini, P
Neuroendocrinology 102, 200-215, 2015
Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity
Bouret, S., Levin, B.E. & Ozanne, S.E
Physiol Rev 95, 47-82, 2015
2014
2013
Semaphorin signaling in the development and function of the gonadotropin hormone-releasing hormone system
Messina A and Giacobini P
Front. Endocrinol., 23 September 2013. doi: 10.3389/fendo.2013.00133, 2013
Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain
Prevot V, Langlet F, Dehouck B
Aging 5:332-334, 2013
Semaphorins in the development, homeostasis and disease of hormone systems
Giacobini P, Prevot V
Semin Cell Dev Biol 24:190-198, 2013
Role of glia in the regulation of gonadotropin-releasing hormone neuronal activity and secretion
Sharif A, Baroncini M, Prevot V
Neuroendocrinology 98:1-15, 2013
Organizational actions of metabolic hormones
Bouret, S.G
Front Neuroendocrinol 34, 18-26, 2013
2011
Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproduction
Bellefontaine N, Hanchate NK, Parkash J, Campagne C, de Seranno S, Clasadonte J, d’Anglemont de Tassigny X, Prevot V
Neuroendocrinology 93:74-89, 2011
Gliotransmission by prostaglandin E2: a prerequisite for GnRH neuronal function
Clasadonte J, Sharif A, Baroncini M, Prevot V
Front Endocrinol 2:1-12, 2011
GnRH neurons directly listen to the periphery
Prevot V
Endocrinology 152: 3589-3591, 2011
2010
Plasticity of neuroendocrine systems
Prevot V
Eur J Neurosci 32:1987-1988, 2010
GnRH nerve terminals, tanycytes and neurohaemal junction remodeling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells
Prevot V, Bellefontaine N, Baroncini M, Sharif A, Hanchate NK, Parkash J, Campagne C, de Seranno S
J Neuroendocrinol 22:639-649, 2010
Function-related structural plasticity of the GnRH system: a role for neuronal-glial-endothelial interactions
Prevot V, Hanchate NK, Bellefontaine N, Sharif A, Parkash J, Estrella C, Allet C, de Seranno S, Campagne C, de Tassigny X, Baroncini M
Front Neuroendocrinol 31:241-258, 2010
ErbB receptor signaling in astrocytes: a mediator of neuron-glia communication in the mature central nervous system
Sharif A, Prevot V
Neurochem Int 57:344-358, 2010
Book Chapters
2018
Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function
Prevot V & Sharif A
Herbison AE & Plant TM. The GnRH neuron and its Control. Wiley. Chapter 10, pp 225. doi 10.1002/9781119233275.ch10
2016
Ontogeny of Neuroendocrine Feeding Circuits
Croizier S & Bouret SG
Dickson SL, Mercer JG (eds) Neuroendocrinology of Appetite. Wiley & Sons Ltd, c3
2015
Puberty in mice and rats
Prevot V
Plant, T.M., Zeleznik, J. (eds) Knobil and Neill’s Physiology of Reproduction. Elsevier, New York, pp 1395-1439, 2015
Endothelial cell plasticity in the normal and injured central nervous system
Vanacker C, Sharif A, Prevot P
Chapter 4, CRC Press, 2015
2014
Neurogenesis and gliogenesis in the postnatal hypothalamus: a new level of plasticity for the regulation of hypothalamic function
Sharif A, Ojeda SR, Prevot V
Junier MP, Kernie SG eds. Endogenous Stem Cell-Based Brain Remodeling in Mammals, Stem Cell Biology and Regenerative Medicine. New York: Springer Science+Business Media, Chapter 6, pp 105-136, 2014
2012
Neuroendocrine control of reproduction
Clarke IJ, Campbell R, Smith JT, Prevot V, Wray S
In: Handbook of Neuroendocrinology (Fink G, Pfaff DW, Levine JE, Eds), Academic Press, San Diego, CA, Chapter 9, pp 197-235, 2012
Isolation and culture of human astrocytes
Sharif A, Prevot V
Methods Mol Biol 814:137-151, 2012
General Audience
2016
Control of fertility: New player identified
Anti-Mullerian hormone: an ovarian hormone exerting hypothalamic feedback?
Catteau-Jonard S, Dewailly D, Prevot V, Cimino I & Giacobini P
Med Sci (Paris), 32:441-444, 2016
Maternal obesity alters social brain programming by altering gut microbiota in progeny
Barbotin AL, Giacobini P, Prévot V
Med Sci (Paris). 32930-932, 2016
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