Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood

Tata BK, Mimouni NEH, Barbotin AL, Malone SA, Loyens A, Pigny P, Dewailly D, Catteau-Jonard S, Sundström-Poromaa I, Piltonen TT, Dal Bello F, Medana C, Prevot V, Classadonte J, Giacobini P

Nature Medicine. 2018. doi:10.1038/s41591-018-0035-5

A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and grey mouse lemur (Microcebus murinus)

Pellegrino G, Trubert C, Terrien J, Pifferi F, Leroy D, Loyens A, Migaud M, Baronicini M, Maurage CA, Fontaine C, Prevot V, Sharif A

J Comp Neurol. 2018. doi: 10.1002/cne.24376


Phenotyping of nNOS Neurons in the Postnatal and Adult Female Mouse Hypothalamus

Chachlaki K, Malone SA, Qualls-Creekmore, Hrabovszky E, Munzberg H, Giacobini P, Ango F, Prevot V

J Comp Neurol. 2017. 10.1002/cne.24257

Tridimensional Visualization and Analysis of Early Human Development

Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chedotal A

Cell. 2017 DOI: http://dx.doi.org/10.1016/j.cell.2017.03.008


Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains

Casoni F, Malone SA, Belle M, Luzzati F, Collier F, Allet C, Hrabovszky ERasika S, Prevot VChédotal V, Giacobini P

Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits

Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, and Bouret

Hum Mol Genet. 25:3208-3215, 2016

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, Gallet S, Gaytan F, Parkash J, Tena-Sempere M, Giacobini P, Prevot V

Nat Neurosci. 2016 19, 835-844 doi:10.1038/nn.4298

Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion

Cimino I, Casoni F, Liu X, Messina A, Parkash J, Soazik P, Catteau-Jonard S, Collier F, Baroncini M, Dewailly D, Pigny P, Prescott M, Campbell R, Herbison A, Prevot V, Giacobini P

Nat Commun. 2016, 7:10055


Semaphorin7A regulates neuroglial plasticity at the adult hypothalamic median eminence

Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong FP, Cagnoni, Schellino RDe Marchis, Mazzone MPasterkamp JR, Tamagnone L, Prevot V, Giacobini P

Nat Commun. 2015, 6:6385 doi:10.1038/ncomms7385.

Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin

Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, and Bouret SG.

Mol Metab. 2015, 4(1):15-24.

Neonatal ghrelin programs development of hypothalamic feeding circuits

Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, and Bouret SG.

J Clin Invest. 2015, 125(2):846-58.


Leptin dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction

Bellefontaine N, Chachlaki K, Parkash J, Vanaker C, Colledge W, d’Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V.

J Clin Invest 124:2550-2559, 2014.

Brain Endothelial Cells Control Fertility through Ovarian-Steroid_dependent Release of Semaphorin 3A

Giacobini P, Parkash J, Campagne C, Messina A, Casoni F, Vanacker C, Langlet F, Hobo B, Cagnoni G, Gallet S, Hanchate NK, Mazur D, Taniguchi M, Mazzone M, Verhaagen J, Ciofi P, Bouret SG, Tamagnone L, Prevot V.

PLoS Biology 12(3):e1001808, 2014.

Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain

Balland E, Dam J, Langlet F, Caron E, Steculorum S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prevot V. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.

Cell Metab 19, 293-301, 2014. (also Cell Metab Previews p. 173-175)


Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

Langlet F, Muller A, Bouret SG, Prevot V, Dehouck B.

J Comp Neurol. 2013521(15):3389-405 doi: 10.1002/cne.23355

Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting

Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B

Cell Metab. 2013 Apr 2;17(4):607-17. doi: 10.1016/j.cmet.2013.03.004..

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7. doi:10.1073/pnas.1212137110.


Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations.

Parkash J, Cimino I, Ferraris N, Casoni F, Wray S, Cappy H, Prevot V, Giacobini P.

J Neurosci. 2012 Nov 21;32(47):16992-7002. doi: 10.1523/JNEUROSCI.3057-12.2012.

RIPping off GABA release in hypothalamic circuits causes obesity.

Bouret SG.

Cell Metab. 2012 Nov 7;16(5):557-8. doi: 10.1016/j.cmet.2012.10.014.

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

Hanchate NK, Giacobini P, Lhuillier P, Parkash J, Espy C, Fouveaut C, Leroy C, Baron S, Campagne C, Vanacker C, Collier F, Cruaud C, Meyer V, García-Piñero A, Dewailly D, Cortet-Rudelli C, Gersak K, Metz C, Chabrier G, Pugeat M, Young J, Hardelin JP, Prevot V, Dodé C.

PLoS Genet. 2012 Aug;8(8):e1002896. doi: 10.1371/journal.pgen.1002896.

Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function.

Caron E, Ciofi P, Prevot V, Bouret SG.

J Neurosci. 2012 Aug 15;32(33):11486-94. doi: 10.1523/JNEUROSCI.6074-11.2012.

Embryonic birthdate of hypothalamic leptin-activated neurons in mice.

Ishii Y, Bouret SG.

Endocrinology. 2012 Aug;153(8):3657-67. doi: 10.1210/en.2012-1328.

Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation.

Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG.

Cell Metab. 2012 Feb 8;15(2):247-55. doi: 10.1016/j.cmet.2011.12.016.

Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits.

Bouret SG, Bates SH, Chen S, Myers MG Jr, Simerly RB.

J Neurosci. 2012 Jan 25;32(4):1244-52. doi: 10.1523/JNEUROSCI.2277-11.2012.

Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.

Hanchate NK, Parkash J, Bellefontaine N, Mazur D, Colledge WH, d’Anglemont de Tassigny X, Prevot V.

J Neurosci. 2012 Jan 18;32(3):932-45. doi: 10.1523/JNEUROSCI.4765-11.2012.

MRI atlas of the human hypothalamus.

Baroncini M, Jissendi P, Balland E, Besson P, Pruvo JP, Francke JP, Dewailly D, Blond S, Prevot V.

Neuroimage. 2012 Jan 2;59(1):168-80. doi: 10.1016/j.neuroimage.2011.07.013.


Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility.

Messina A, Ferraris N, Wray S, Cagnoni G, Donohue DE, Casoni F, Kramer PR, Derijck AA, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P.

Hum Mol Genet. 2011 Dec 15;20(24):4759-74. doi: 10.1093/hmg/ddr403.

Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.

Clasadonte J, Poulain P, Hanchate NK, Corfas G, Ojeda SR, Prevot V.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16104-9. doi: 10.1073/pnas.1107533108.

Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring.

Steculorum SM, Bouret SG.

Endocrinology. 2011 Nov;152(11):4171-9. doi: 10.1210/en.2011-1279.


Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle.

Parkash J, d’Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buée-Scherrer V, Prevot V.

Endocrinology. 2010 Jun;151(6):2723-35. doi: 10.1210/en.2010-0007.

Role of estradiol in the dynamic control of tanycyte plasticity mediated by vascular endothelial cells in the median eminence.

De Seranno S, d’Anglemont de Tassigny X, Estrella C, Loyens A, Kasparov S, Leroy D, Ojeda SR, Beauvillain JC, Prevot V.

Endocrinology. 2010 Apr;151(4):1760-72. doi: 10.1210/en.2009-0870.

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.

Mullier A, Bouret SG, Prevot V, Dehouck B.

J Comp Neurol. 2010 Apr 1;518(7):943-62. doi: 10.1002/cne.22273.

Distribution of leptin-sensitive cells in the postnatal and adult mouse brain.

Caron E, Sachot C, Prevot V, Bouret SG

J Comp Neurol. 2010 Feb 15;518(4):459-76. doi: 10.1002/cne.22219.

Sex steroid hormones-related structural plasticity in the human hypothalamus.

Baroncini M, Jissendi P, Catteau-Jonard S, Dewailly D, Pruvo JP, Francke JP, Prevot V.

Neuroimage. 2010 Apr 1;50(2):428-33. doi: 10.1016/j.neuroimage.2009.11.074.


The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism

Prevot V, Dehouck B, Sharif A, Ciofi P, Giacobini P, Clasadonte J

Endocrine Reviews. 2018. 1;39(3):333-368. doi: 10.1210/er.2017-00235

The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus

Clasadonte J & Prevot V

Nature Reviews Endocrinology. 2018, doi:10.1038/nrendo.2017.124


The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus

Chachlaki K, Garthwaite J, Prevot V

Nature Reviews Endocrinology. 2017, doi:10.1038/nrendo.2017.69

Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility

Manfredi-Lozano M, Roa J, Tena-Sempere M

Frontiers in Neuroendocrinology. 2017, doi: 10.1016/j.yfrne.2017.07.008

When size matters: how astrocytic processes shape metabolism

Sharif A, Prevot V

Cell Metabolism. 2017, doi:10.1016/j.cmet.2017.04.016


Hypothalamic microRNAs flip the switch for fertility

Messina A, Prevot V

Oncotarget. 2016, DOI: 10.18632/oncotarget.14646

Reproduction: A kiss to set the rhythm

Shruti S, Prevot V

elife. 2016, doi:e19823

Programming the Brain from the Womb: Maternal Obesity Perturbs the Hypothalamic Blood-Brain Barrier

Duquenne, M., Dehouck, B. & Prevot, V

Endocrinology, 157:2201-2203, 2016

Coexpression profiles reveal hidden gene networks

Chachlaki & Prevot

PNAS (doi: 10.1073/pnas.1600717113)



Tanycytes: a gateway to the metabolic hypothalamus

Langlet, F

J Neuroendocrinol 26, 753-760, 2014


Semaphorin signaling in the development and function of the gonadotropin hormone-releasing hormone system

Messina A and Giacobini P

Front. Endocrinol., 23 September 2013doi: 10.3389/fendo.2013.00133, 2013

Flipping the tanycyte switch: how circulating signals gain direct access to the metabolic brain

Prevot V, Langlet F, Dehouck B

Aging 5:332-334, 2013

Semaphorins in the development, homeostasis and disease of hormone systems

Giacobini P, Prevot V

 Semin Cell Dev Biol 24:190-198, 2013

Role of glia in the regulation of gonadotropin-releasing hormone neuronal activity and secretion

Sharif A, Baroncini M, Prevot V

Neuroendocrinology 98:1-15, 2013

Organizational actions of metabolic hormones

Bouret, S.G

Front Neuroendocrinol 34, 18-26, 2013


Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproduction

Bellefontaine N, Hanchate NK, Parkash J, Campagne C, de Seranno S, Clasadonte J, d’Anglemont de Tassigny X, Prevot V

Neuroendocrinology 93:74-89, 2011

Gliotransmission by prostaglandin E2: a prerequisite for GnRH neuronal function

Clasadonte J, Sharif A, Baroncini M, Prevot V

Front Endocrinol 2:1-12, 2011

GnRH neurons directly listen to the periphery

Prevot V

Endocrinology 152: 3589-3591, 2011


Plasticity of neuroendocrine systems

Prevot V

Eur J Neurosci 32:1987-1988, 2010

GnRH nerve terminals, tanycytes and neurohaemal junction remodeling in the adult median eminence: functional consequences for reproduction and dynamic role of vascular endothelial cells

Prevot V, Bellefontaine N, Baroncini M, Sharif A, Hanchate NK, Parkash J, Campagne C, de Seranno S

J Neuroendocrinol 22:639-649, 2010

Function-related structural plasticity of the GnRH system: a role for neuronal-glial-endothelial interactions

Prevot V, Hanchate NK, Bellefontaine N, Sharif A, Parkash J, Estrella C, Allet C, de Seranno S, Campagne C, de Tassigny X, Baroncini M

Front Neuroendocrinol 31:241-258, 2010

ErbB receptor signaling in astrocytes: a mediator of neuron-glia communication in the mature central nervous system

Sharif A, Prevot V

Neurochem Int 57:344-358, 2010


Unveiling the Importance of Glia and Vascular Endothelial Cells in the Control of GnRH Neuronal Function

Prevot V & Sharif A

Herbison AE & Plant TM. The GnRH neuron and its Control. Wiley. Chapter 10, pp 225. doi 10.1002/9781119233275.ch10


Ontogeny of Neuroendocrine Feeding Circuits

Croizier S & Bouret SG

Dickson SL, Mercer JG (eds) Neuroendocrinology of Appetite. Wiley & Sons Ltd, c3


Puberty in mice and rats

Prevot V

Plant, T.M., Zeleznik, J. (eds) Knobil and Neill’s Physiology of Reproduction. Elsevier, New York, pp 1395-1439, 2015

Endothelial cell plasticity in the normal and injured central nervous system

Vanacker C, Sharif A, Prevot P

Chapter 4, CRC Press, 2015


Neurogenesis and gliogenesis in the postnatal hypothalamus: a new level of plasticity for the regulation of hypothalamic function

Sharif A, Ojeda SR, Prevot V

Junier MP, Kernie SG eds. Endogenous Stem Cell-Based Brain Remodeling in Mammals, Stem Cell Biology and Regenerative Medicine. New York: Springer Science+Business Media, Chapter 6, pp 105-136, 2014


Neuroendocrine control of reproduction

Clarke IJ, Campbell R, Smith JT, Prevot V, Wray S

In: Handbook of Neuroendocrinology (Fink G, Pfaff DW, Levine JE, Eds), Academic Press, San Diego, CA, Chapter 9, pp 197-235, 2012

Isolation and culture of human astrocytes

Sharif A, Prevot V

Methods Mol Biol 814:137-151, 2012


Control of fertility: New player identified

Anti-Mullerian hormone: an ovarian hormone exerting hypothalamic feedback?

Catteau-Jonard S, Dewailly D, Prevot V, Cimino I & Giacobini P

 Med Sci (Paris), 32:441-444, 2016

Maternal obesity alters social brain programming by altering gut microbiota in progeny

Barbotin AL, Giacobini P, Prévot V

Med Sci (Paris). 32930-932, 2016

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