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Abbreviations:
ARH/me: arcuate nucleus of the hypothalamus/médian eminence; GnRH: gonadotropin releasing hormone; POA: preoptic region; PVH: Periventricular nucleus of the hypothalamus; DMH: dorsomedial nucleus of the hypothalamus; LHA: lateral hypothalamic area; AMH: anti-Mullerian hormone
It also aims to evaluate how pathological conditions (obesity, diabetes etc.) affect these neurobiological events and, conversely, how the impairment of communication between the brain and the periphery renders the organism prone to developing such conditions (obesity, diabetes, precocious and/or delayed puberty and infertility).
Our laboratory brings together in a single setting a wide range of theoretical knowledge and technical expertise in its fields of research and is able to investigate physiological and pathological processes from the molecular and genetic/epigenetic levels to that of human patients, thanks to the close interaction between basic scientists and clinicians.
For the excellence of our work, our laboratory has been classified as “remarkable” (the highest “grade” attributed to French research laboratories) by our evaluating bodies in 2014.
Our Lab is also actively involved in several Local (FHU 1000 days for Health, DN2M), National (Société de Neuroendocrinologie (SNE), GDR repro, Société des neurosciences, Club de cellules gliales) and International research networks including LARC-Neurosciences, GnRH network, and FENS.
How peripheral signals are able to bypass the "gateway" of the brain, signaling the metabolic status of the organism, modifying behavioural and physiological activity.
Disorders affecting our ability to reproduce can cause severe emotional and psychological issues and often have tight association to metabolic syndromes.
How the birth of new hypothalamic neurons and glia may contribute to the regulation of metabolic and reproductive control networks.
Even though there have been many advances in understanding how body weight is regulated, translating this knowledge into effective treatment strategies has so far proven ineffective
How neuronal networks that impinge on GnRH neurons control GnRH release, timing the onset of puberty and the maintenance of reproductive capacity.
As populations live longer, it becomes more important for us to understand how common disorders such as obesity contribute to neurodegenerative disorders such as Alzheimer's Disease.
Measuring reproductive hormones allows us to decipher how endocrine feedback loops are regulated
Understanding the electrical activity of neurons and non-neuronal cells gives insight into how networks are formed and co-ordinated to regulate downstream outcomes
Often seemingly simple phenotypes such as obesity may be caused by complex changes in metabolic parameters that we assess using metabolic cages
Using ISH and IF allows an appreciation of the spatial expression of genes and proteins, enhanced by the use of tissue clearing and light sheet microscopy techniques.
From gonadectomies to stereotaxic virus delivery, precise manipulations of experimental models can allow us to answer complex questions.
Beyond neuronal signals and hormonal changes, physiological and behavioral changes occur from changes in reproductive attitudes to olfactory behavior.
